Skip to main content

#PreventDementia: what is your lifetime risk of dementing?

"What is it that one wants to achieve?"

'Traditionally preventive medicine is a combination of medical practices that are designed to avoid disease and illness. It is a proactive approach to patient care with the aim of using evidence-based preventative measures to ensure that any sickness is minimised and detected early so that a patient has the best chance of recovery to optimum health.' This definition is based on a medicalised worldview of preventive medicine. Why can't we use social or political practices to avoid disease and illness? Surely the aim is better population health and is not necessarily about the individual? A healthier population will have a better quality of life, less need for healthcare and in theory should be happier and more content than an unhealthy population. 


I have been criticised for jumping onto the social determinants of health bandwagon now that it is a hot topic. I counter this by stating that it is only a hot topic because COVID-19 exposed the huge and embarrassing inequalities in our country. Another reason has been the current Tory government’s levelling-up agenda to address inequality across the country. The following paper from our Preventive Neurology Unit is another example of how socioeconomic deprivation plays out over a lifetime and is strongly associated with dying from dementia and at a younger age.


Why is this so important?

It is so important because if you believe like I do that dementia is preventable then you have to focus on the so-called modifiable risk factors. It is clear that most of the modifiable risk factors for dementia are strongly associated with deprivation, i.e. low-educational status, sedentary lifestyle, smoking, obesity and hypertension to name a few. So to target these without sound government policy to tackle the root cause is folly.

If this government was serious about their levelling-up agenda and really wanted to tackle inequality they would have dusted off the Black Report into health inequality from 1980 and implemented its recommendations with some modern twists. One modern twist is getting everyone digitally literate with access to the internet. Why didn’t Rishi Sunak mandate that as part of a ‘no child left behind’ policy every school child gets a computer and mandatory access to the internet? Why wasn’t more money allocated to state education to level it up to what is available in the private sector? There has never been a better opportunity, than post-COVID, to transform school education and start to address dementia risk at school.

It is shameful that it is over 40 years since the Black report was published and we still having the same debate. Only this time we have so much better data on the real cost inequality has on society. It doesn’t only affect the lower socioeconomic strata of society, but the upper strata as well. Everyone suffers when there are large inequalities in society.

Every now and then an event or a piece of research has a profound effect on society. It goes viral and it shames us and out politicians into action. This is how protest movements such as #MeToo, #BlackLivesMatter and #TakeBackTheStreets happen. I am hoping this piece of research, which I am so proud of, makes #ThinkSocial, #LevellingUp, #NoChildLeftBehind, #PreventDementia, #ThinkBrainHealth go viral. 

Don't we owe it to the next generation to try and prevent them from dying early from dementia? We also need to ask ourselves about what kind of society we want to live in?

Jitlal et al. The influence of socioeconomic deprivation on dementia mortality, age at death and quality of diagnosis: a nationwide death records study in England and Wales 2001-2017. MedRxiv doi: https://doi.org/10.1101/2020.09.28.20203000

Background: Socioeconomic deprivation is postulated to be an important determinant of dementia risk, mortality, and access to diagnostic services. Nevertheless, premature mortality from other causes and under-representation of deprived individuals in research cohorts may lead to this effect being overlooked.

Methods: We obtained Office of National Statistics (ONS) mortality data where dementia was recorded as a cause of death in England and Wales from 2001 to 2017, stratified by age, diagnosis code and UK Index of Multiple Deprivation (IMD) decile. We calculated standardised mortality ratios (SMR) for each IMD decile, adjusting for surviving population size in each IMD decile and age stratum. In those who died of dementia, we used ordinal logistic regression to examine the effect of deprivation on the likelihood of being older at death. We used logistic regression to test the effect of deprivation on the likelihood of receiving a diagnosis of unspecified dementia, a proxy for poor access to specialist diagnostic care.

Results: 578,623 deaths due to dementia in people over the age of 65 were identified between 2001-2017. SMRs were similar across the three most deprived deciles (1-3) but progressively declined through deciles 4-10 (Mean SMR [95%CI] in decile 1: 0.528 [0.506 to 0.550], decile 10: 0.369 [0.338 to 0.400]). This effect increased over time with improving ascertainment of dementia. In 2017, 14,837 excess dementia deaths were attributable to deprivation (21.5% of the total dementia deaths that year). There were dose-response effects of deprivation on the likelihood of being older at death with dementia (odds ratio [95%CI] for decile 10 (least deprived): 1.31 [1.28 to 1.33] relative to decile 1), and on the likelihood of receiving a diagnosis of unspecified dementia (odds ratio [95%CI] for decile 10: 0.78 [0.76 to 0.80] relative to decile 1).

Conclusions: Socioeconomic deprivation in England and Wales is associated with increased dementia mortality, younger age at death with dementia, and poorer access to specialist diagnosis. Reducing social inequality may be an important strategy for the prevention of dementia mortality.

Comments

  1. I'm not disagreeing with anything here, but I want to point out- What is it one wants to achieve? I think of my father who succumbed, with very little original comorbidity, after five or ten years (depending on how you count it, and probably longer). He was not poor. Those five or ten years were not happy years. At one point in that time period, he would have told you, that staying alive wasn't worth it; he just at that point was unable to make such a declaration.

    So at what point does one want to admit that "life isn't worth it? He had good care which extended his life. There was lots of suffering for him though, towards the last few years (the years that would make a statistical difference when compared to others). Only good part was, for the most part, that it wasn't "him" any more, doing the suffering. Very bad situation no matter how you spin it.

    ReplyDelete
    Replies
    1. Re: "What is it one wants to achieve?"

      Better population health. Preventive medicine is about looking after populations and not individuals.

      Delete

Post a Comment

Popular posts from this blog

Corpulence and poverty

Since stating my intention to join the  #BackTo21  campaign to get my BMI back to what it was when I was 21 years of age, I have had several emails and direct messages on social media questioning the wisdom of my intention.  Photo by NeONBRAND on Unsplash It is clear that despite BMI being a relatively poor metric of health there is overwhelming evidence that at a population level it predicts poor health outcomes. Importantly there is new data that indicates the target BMI for the prevention of type 2 diabetes and the metabolic syndrome depends on your ethnicity. For people of South Asian origin, there is a call to reset the BMI cutoff to 23.9, which for most people is within the normal range. At the same time, there is a call to classify obesity as an important social determinant of health. Arnaud Chiolero argues below for using BMI as a socioeconomic indicator. Do you agree? Isn’t it quite amazing that in a previous era corpulence was a sign of affluence, whereas in th...

Moved to substack

Dear Reader We have moved the preventive neurology unit blog to a new platform called substack . Google is discontinuing its Feedburner and has not added many new features to blogger for some time, which is why we have decided to move the site.  https://preventiveneurology.substack.com/  Thanks Gavin Giovannoni

To be teetotal or not

In summary, any form and any amount of alcohol consumption is unhealthy for the brain. Photo by Hush Naidoo on Unsplash He was only 64 when his daughter noticed that his forgetfulness had started to impact on his ability to function independently. Her father had forgotten to pay the gas and electricity bill and social services had contacted her as next of kin to find out why. It was clear that years of excessive alcohol was having an impact on his memory. The scenario above is one that is played out across society thousands of times if not hundreds of thousands of times. This is why the study below from the UK biobank is so worrying; when it comes to brain volume, a crude measure of the brain's neuronal and cognitive reserve, there is no safe alcohol consumption limit. Importantly, comorbidities such as high blood pressure and obesity interacted with alcohol consumption to reduce brain health. Not surprisingly binging on alcohol made things worse and this was over and above the vo...